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Scientific publications

At Day One, we use the power of leading-edge science to improve patient outcomes.

We believe timely and transparent dissemination of data from our clinical trials and other studies is essential to inform clinical decision making and to advance scientific understanding. Our comprehensive list of publications is below.
June 2023
Clinical activity of pan-RAF inhibitor tovorafenib in the registrational pediatric low-grade glioma arm of the phase 2 FIREFLY-1 (PNOC026) study.
Kilburn L, Khuong-Quang D-A, Nysom K, Landi D, Ziegler DS, Hernáiz Driever P, Leary S, Bailey S, Van der Lugt J, Perreault S, Waanders AJ, Baxter P, Witt O, Hargrave D, McCowage G, Zhao X, Da Costa D, Cox MC, Manley P, Hansford JR. LGG-09. Clinical activity of pan-RAF inhibitor tovorafenib in the registrational pediatric low-grade glioma arm of the phase 2 FIREFLY-1 (PNOC026) study. Neuro-Oncol. 2023(suppl 1);i57. (ABSTRACT CITATION ID: NOAD073.218)
June 2023
Clinical activity of pan-RAF inhibitor tovorafenib in the registrational pediatric low-grade glioma arm of the phase 2 FIREFL Y-1 (PNOC026) study
Lindsay Kilburn, Dong-Anh Khuong-Quang, Karsten Nysom, Daniel Landi, David S. Ziegler, Pablo Hernaiz Driever, Sarah Leary, Simon Bailey, Jasper Van der Lugt, Sebastien Perreault, Angela J. Waanders, Patricia Baxter, Olaf Witt, Darren Hargrave, Geoffrey McCowage, Xin Zhao, Daniel Da Costa, Michael C. Cox, Peter Manley, Jordan R. Hansford
2023 ASCO Annual Meeting, June 2-6, 2023, Chicago, IL & Online. Abstract number 10004
June 2023
LOGGIC/FIREFLY-2: A phase 3, randomized trial of tovorafenib vs. chemotherapy in pediatric and young adult patients with newly diagnosed low-grade glioma harboring an activating RAF alteration
Cornelis M. van Tilburg, Lindsay Kilburn, Erin Crotty, Amy A. Smith, Sebastien Perreault, Andrea T. Franson, Nada Jabado, Lindsey M. Hoffman, Rene Schmidt, Antoinette Y.N. Schoutenvan Meeteren, Astrid Sehested, Enrico Opocher, Pablo Hernáiz Driever, Shivaram Avula, David S. Ziegler, Jiaheng Qiu, Li-Pen Tsao, Peter Manley, Darren Hargrave, Olaf Witt
ASCO Annual Meeting 2023: Abstract TPS10067
June 2023
Healthcare resource use for pediatric low-grade glioma care: a cohort of linked electronic health records and claims data
Tabitha Cooney, Sandie Yu, Shailaja Daral, Michelle A Field, Blake Krebs, Mark Kieran, Peter Manley, Sandya Govinda Raju, Susan Zelt
2023 ASCO Annual Meeting: Abstract 10038
May 2023
Phase 1 study of the pan RAF inhibitor tovorafenib in patients with advanced solid tumors followed by dose expansion in patients with metastatic melanoma
Rasco DW, Medina T, Corrie P, Pavlick AC, Middleton MR, Lorigan P, Hebert C, Plummer R, Larkin J, Agarwala SS, Daud AI, Qiu J, Bozon V, Kneissl M, Barry E, Olszanski AJ. [published online ahead of print May 23, 2023]. Cancer Chemother Pharmacol. 2023;92:15-28.
May 2023
Chart audit in pediatric low-grade glioma: molecular testing and treatment patterns
David Lee, Jorge Caravia, Kevin Lam, Judith Kulich, Katie Blodget, Sandya Govinda Raju
2023 ASPHO Conference: Poster 261