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Scientific publications

At Day One, we use the power of leading-edge science to improve patient outcomes.

We believe timely and transparent dissemination of data from our clinical trials and other studies is essential to inform clinical decision making and to advance scientific understanding. Our comprehensive list of publications is below.
April 2024
Phase 1 dose escalation and expansion study of the PTK7-targeted antibody-drug conjugate DAY301 in patients with locally advanced or metastatic solid tumors. 
Sommerhalder D, Durm GA, Maki R, LoRusso PM, Piha-Paul SA, Bedard PL, Chau N, Venetsanakos E, Hume S, Qiu J, Martorana M, Kieran MW, Da Costa D, Lakhani N.
Abstract CT196. Phase 1 dose escalation and expansion study of the PTK7-targeted antibody-drug conjugate DAY301 in patients with locally advanced or metastatic solid tumors. Poster presentation at: AACR (American Association for Cancer Research) Annual Meeting 2025; April 29, 2025; Chicago, IL.
April 2024
Sequencing MEK inhibitor therapy after tovorafenib in BRAF fusion-driven cancers: Preclinical evidence of sustained tumor regression. Poster presentation at: AACR (American Association for Cancer Research) Annual Meeting 2025; April 28, 2025; Chicago, IL.
Perino S, Wang Y, Rastogi S, Damayanti NP, Pollok KE, Govinda Raju S, Kieran MW, Blackman SC, Venetsanakos E.
Abstract 1727. Sequencing MEK inhibitor therapy after tovorafenib in BRAF fusion-driven cancers: Preclinical evidence of sustained tumor regression. Poster presentation at: AACR (American Association for Cancer Research) Annual Meeting 2025; April 28, 2025; Chicago, IL.
March 2025
Preclinical activity of the type II RAF inhibitor tovorafenib in tumor models harboring either a BRAF fusion or an NF1-loss of function mutation
Rastogi S, Perino S, Lal-Nag M, Wang Y, Blackman SC, Eleni Venetsanakos E.
Preclinical activity of the type II RAF inhibitor tovorafenib in tumor models harboring either a BRAF fusion or an NF1-loss of function mutation [published online ahead of print March 20, 2025]. Cancer Res. Commun. 2025.
December 2024
Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial
Nysom K, Kilburn LB, Leary SES, Landi DB, de Vos-Kerkhof E, Perreault S, Witt O, Ziegler DS, Hernáiz Driever P, Franson AT, Baxter PA, Whipple NS, Kline C, Segal D, Jabado N, Bailey S, McCowage G, Hansford JR, Khuong-Quang D-A, Gottardo NG, Hassall TE, Han JW, Oren MY, Chi SN, Qiu J, Da Costa D, Govinda Raju S, Manley P, Hargrave D.
Radiographic and visual response to the type II RAF inhibitor tovorafenib in children with relapsed/refractory optic pathway glioma in the FIREFLY-1 trial [published online ahead of print December 19, 2024]. NeuroOncol. 2024.
November 2024
Type II RAF inhibitor tovorafenib in relapsed/refractory (r/r) pediatric low-grade glioma (pLGG): Results from patients on a drug holiday (DH) in the phase 2 FIREFLY-1 trial.
Perreault S, Khuong-Quang D-A, Kilburn LB, Landi DB, Leary SES, Bailey S, Larouche V, Nysom K, Hernáiz Driever P, Baxter PA, Witt O, Yalon Oren M, Abdelbaki MS, Kline C, Whipple NS, Ziegler DS, van der Lugt J, Hassall TE, Gerber NU, Segal D, Hansford JR, McCowage G, Kang HJ, Han JW, Hargrave DH, Franson AT, Toledano H, Jabado N, Gottardo NG, Chi SN, Oren L, Tan EEK, Mueller S, Hoke ME, Kim Y, Walter A, Da Costa D, Manley P, Waanders AJ.
CTNI-09. Type II RAF inhibitor tovorafenib in relapsed/refractory (r/r) pediatric low-grade glioma (pLGG): Results from patients on a drug holiday (DH) in the phase 2 FIREFLY-1 trial. Poster presentation at: 29th Annual Meeting and Education Day of the Society for Neuro-Oncology; November 22, 2024; Houston, TX.
November 2024
Health-related Quality of Life (HRQOL) in the phase 2 FIREFLY-1 (PNOC026) trial of the type II RAF inhibitor tovorafenib in relapsed/refractory (r/r) pediatric low-grade glioma (pLGG).
Peipert J(D), Baxter PA, Yu S, Oestreicher N, Zelt S, Hernáiz Driever P, Bailey S, McCowage G, Ziegler DS, Witt O, Kang HJ, Hassall TE, Han JW, Franson AT, Yalon Oren M, Toledano H, Larouche V, Abdelbaki MS, Jabado N, Gottardo NG, Gerber NU, Whipple NS, Segal D, Chi SN, Oren L, Tan EK, Mueller S, Kilburn LB, Nysom K, Khuong-Quang D-A, Landi DB, van der Lugt J, Leary SES, Perreault S, Waanders AJ, Hargrave D, Kline C, McKenna C, Manley P, Govinda Raju S, Hansford JR.
NCOG-05. Health-related Quality of Life (HRQOL) in the phase 2 FIREFLY-1 (PNOC026) trial of the type II RAF inhibitor tovorafenib in relapsed/refractory (r/r) pediatric low-grade glioma (pLGG). Poster and 4-minute rapid report oral presentation at: 29th Annual Meeting and Education Day of the Society for Neuro-Oncology; November 22, 2024; Houston, TX.